Ontology highlight
ABSTRACT:
SUBMITTER: Juric I
PROVIDER: S-EPMC6483256 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
PLoS computational biology 20190415 4
Hi-C and chromatin immunoprecipitation (ChIP) have been combined to identify long-range chromatin interactions genome-wide at reduced cost and enhanced resolution, but extracting information from the resulting datasets has been challenging. Here we describe a computational method, MAPS, Model-based Analysis of PLAC-seq and HiChIP, to process the data from such experiments and identify long-range chromatin interactions. MAPS adopts a zero-truncated Poisson regression framework to explicitly remov ...[more]