Ontology highlight
ABSTRACT:
SUBMITTER: Arega Y
PROVIDER: S-EPMC7767989 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in genetics 20201214
Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) is an important experimental method for detecting specific protein-mediated chromatin loops genome-wide at high resolution. Here, we proposed a new statistical approach with a mixture model, chromatin interaction analysis using mixture model (ChIAMM), to detect significant chromatin interactions from ChIA-PET data. The statistical model is cast into a Bayesian framework to consider more systematic biases: the genomic distance ...[more]