Ontology highlight
ABSTRACT:
SUBMITTER: Uehara M
PROVIDER: S-EPMC6484015 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Uehara Mayuko M Li Xiaofei X Sheikhi Amir A Zandi Nooshin N Walker Brian B Saleh Bahram B Banouni Naima N Jiang Liwei L Ordikhani Farideh F Dai Li L Yonar Merve M Vohra Ishaan I Kasinath Vivek V Orgill Dennis P DP Khademhosseini Ali A Annabi Nasim N Abdi Reza R
Scientific reports 20190425 1
A primary goal in the management of burn wounds is early wound closure. The use of skin allografts represents a lifesaving strategy for severe burn patients, but their ultimate rejection limits their potential efficacy and utility. IL-6 is a major pleiotropic cytokine which critically links innate and adaptive immune responses. Here, we devised anti-IL-6 receptor eluting gelatin methacryloyl (GelMA) biomaterials (GelMA/anti-IL-6), which were implanted at the interface between the wound beds and ...[more]