HLA-G dimer targets Granzyme B pathway to prolong human renal allograft survival.

ABSTRACT: Human leukocyte antigen G (HLA-G), a nonclassic HLA class Ib molecule involved in the maintenance of maternal tolerance to semiallogeneic fetal tissues during pregnancy, has emerged as a potential therapeutic target to control allograft rejection. We demonstrate here that the level of soluble HLA-G dimer was higher in a group of 90 patients with a functioning renal allograft compared with 40 patients who rejected (RJ) their transplants. The HLA-G dimer level was not affected by demographic status. One of the potential mechanisms in tissue-organ allograft rejection involves the induction of granzymes and perforin, which are the main effector molecules expressed by CD8⁺ cytotoxic T lymphocytes and function to destroy allogeneic transplants. Using genomics and molecular and cellula

SUBMITTER: Ajith A 

PROVIDER: S-EPMC6436663 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature