Ontology highlight
ABSTRACT:
SUBMITTER: Shu Z
PROVIDER: S-EPMC6484311 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Shu Zhiping Z Gao Yuan Y Zhang Guopeng G Zhou Yu Y Cao Jing J Wan Dongyi D Zhu Xiaohua X Xiong Wenqian W
Journal of cellular and molecular medicine 20190301 5
The Hippo pathway is an evolutionarily conserved regulator of organ size and tumorigenesis that negatively regulates cell growth and survival. Whether the Hippo pathway regulates cell metabolism is unknown. Here, we report that in the nucleus of hepatocytes, Yes-associated protein(YAP)-the terminal effector of the Hippo pathway-directly interacts with sterol regulatory element binding proteins (SREBP-1c and SREBP-2) on the promoters of the fatty acid synthase (FAS) and 30-hydroxylmethyl glutaryl ...[more]