Ontology highlight
ABSTRACT:
SUBMITTER: Yang X
PROVIDER: S-EPMC5668365 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Yang Xiaoli X Wu Feixiang F Chen Jiankang J Wang Cui C Zhu Yongjie Y Li Feng F Hao Qinfang Q Duan Cuijuan C Wang Li L Ma Xueping X Zou Deyong D Luo Li L Zhao Yiwen Y Guan Kai K Cao Yuan Y Zhang Pingping P Zhou Pengyu P Ma Shengli S Yan Zhifeng Z Li Jia J Zhang Yanhong Y Wei Congwen C Zhong Hui H
Scientific reports 20171102 1
Elevated Golgi phosphoprotein 2 (GP73, also known as GOLPH2 or GOLM1) expression in serum and liver, which can be induced by viral infection and cytokine treatments, is intimately connected with liver disease, including acute hepatitis, cirrhosis and hepatocellular carcinoma (HCC). However, its pathogenic roles in hepatic diseases have never been clarified in detail. Here, we showed that the upregulated GP73 is indispensable for SREBPs activation and lipogenesis. Notably, GP73 overexpression enh ...[more]