Notch1 activates angiogenic regulator Netrin4 in endothelial cells.
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ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC6484422 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Notch1 activates angiogenic regulator Netrin4 in endothelial cells.
Liu Qiang Q Allen Thaddeus D TD Song Wei W Wada Youichiro Y Lobe Corrinne G CG Liu Ju J
Journal of cellular and molecular medicine 20190219 5
Netrin4 (NTN4) is a chemotropic factor that regulates angiogenesis. We found that endothelial expression of the activated, intracellular domain of Notch1 (NICD1), significantly up-regulated NTN4 mRNA as well as intracellular NTN4 protein in both transgenic mice and cultured human umbilical vein endothelial cells (HUVECs). Notch1 activation also increased NTN4 secretion from HUVECs. We subsequently demonstrated that NICD1 bound to CSL (CBF1, Suppressor of Hairless, Lag-1), a core component of Not ...[more]
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