Ontology highlight
ABSTRACT:
SUBMITTER: Ge X
PROVIDER: S-EPMC6484688 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Ge Xiaolu X Li Gui-Yuan GY Jiang Lin L Jia Liqing L Zhang Zhezhe Z Li Xiaoling X Wang Ranran R Zhou Ming M Zhou Yanhong Y Zeng Zhaoyang Z Xiang Juanjuan J Li Zheng Z
Oncogene 20190107 16
Long noncoding RNAs (lncRNAs) play an important role in lung adenocarcinoma (LUAD) metastasis. Here, we found that lncRNA chromatin-associated RNA 10 (CAR10) was upregulated in the tumor tissue of patients with LUAD and enhanced tumor metastasis in vitro and in vivo. Mechanistically, CAR10 induced epithelial-to-mesenchymal transition (EMT) by directly binding with miR-30 and miR-203 and then regulating the expression of SNAI1 and SNAI2. CAR10 overexpression was positively correlated with a poor ...[more]