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The Differential Association between Muscle Strength and Diabetes Mellitus According to the Presence or Absence of Obesity.

ABSTRACT: Background:Muscle strength can be affected by body mass index. In the present study, we compared the association between the diabetes mellitus (DM) and muscle strength according to obesity. Methods:We analyzed the association between DM and muscle strength using the Korea National Health and Nutrition Examination Survey 2014 to 2016 data weighted to represent the Korean population aged between 30 and 79 years old. Muscle strength was classified into age- and sex-specific quartiles (Qs) of handgrip strength, with the lowest Q defined as "low muscle strength (LMS)." Results:Muscle strength was positively associated with body mass index in both sexes (P<0.001); the prevalence of obesity increased by 30% in male (odds ratio [OR], 1.300; 95% confidence interval [CI], 1.231-1.373) and 12% in female (OR, 1.122; 95% CI, 1.062-1.185), respectively, per one Q of muscle strength. In contrast, the prevalence of DM decreased as muscle strength increased (OR per one Q, 0.926; 95% CI, 0.862-0.996 in male and OR per one Q, 0.917; 95% CI, 0.854-0.986 in female). LMS was significantly associated with DM even following adjustment for age, sex, family history of DM, abdominal obesity, dyslipidemia, and hypertension (OR, 1.328; 95% CI, 1.133-1.558). Stratified analysis according to obesity status showed that it remained significant only in nonobese populations (OR, 1.513; 95% CI, 1.224-1.870 in nonobese participants and OR, 1.124; 95% CI, 0.879-1.437 in obese participants). Conclusion:LMS was independently associated with DM in the Korean population aged between 30 and 79 years. However, obesity-stratified analysis revealed that it was significant only in the nonobese population.

SUBMITTER: Koo BK

PROVIDER: S-EPMC6484941 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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The Differential Association between Muscle Strength and Diabetes Mellitus According to the Presence or Absence of Obesity.

Koo Bo Kyung BK

Journal of obesity & metabolic syndrome 20190330 1

<h4>Background</h4>Muscle strength can be affected by body mass index. In the present study, we compared the association between the diabetes mellitus (DM) and muscle strength according to obesity.<h4>Methods</h4>We analyzed the association between DM and muscle strength using the Korea National Health and Nutrition Examination Survey 2014 to 2016 data weighted to represent the Korean population aged between 30 and 79 years old. Muscle strength was classified into age- and sex-specific quartiles ...[more]

PMID: 31089579

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Project description:IntroductionPrevious studies indicated an association between fetal overgrowth and maternal obesity independent of gestational diabetes mellitus (GDM). However, the underlying mechanisms beyond this possible association are not completely understood. This study investigates metabolic changes and their association with fetal and neonatal biometry in overweight and obese mothers who remained normal glucose-tolerant during gestation.Material and methodsIn this prospective cohort study 893 women who did not develop GDM were categorized according to their pregestational body mass index (BMI): 570 were normal weight, 220 overweight and 103 obese. Study participants received a broad metabolic evaluation before 16 weeks and were followed up until delivery to assess glucose levels during the oral glucose tolerance test (OGTT) at mid-gestation as well as fetal biometry in ultrasound and pregnancy outcome data.ResultsIncreased maternal BMI was associated with an adverse metabolic profile at the beginning of pregnancy, including a lower degree of insulin sensitivity (as assessed by the quantitative insulin sensitivity check index) in overweight (mean difference: -2.4, 95% CI -2.9 to -1.9, p < 0.001) and obese (mean difference: -4.3, 95% CI -5.0 to -3.7, p < 0.001) vs normal weight women. Despite not fulfilling diagnosis criteria for GDM, overweight and obese mothers showed higher glucose levels at fasting and during the OGTT. Finally, we observed increased measures of fetal subcutaneous tissue thickness in ultrasound as well as higher proportions of large-for-gestational-age infants in overweight (18.9%, odds ratio [OR] 1.74, 95% CI 1.08-2.78, p = 0.021) and obese mothers (21.0%, OR 1.99, 95% CI 1.06-3.59, p = 0.027) vs normal weight controls (11.8%). The risk for large for gestational age was further determined by OGTT glucose (60 min: OR 1.11, 95% CI 1.02-1.21, p = 0.013; 120 min: OR 1.13, 95% CI 1.02-1.27, P = 0.025, for the increase of 10 mg/dL) and maternal triglyceride concentrations (OR 1.11, 95% CI 1.01-1.22, p = 0.036, for the increase of 20 mg/dL).ConclusionsMothers affected by overweight or obesity but not GDM had a higher risk for fetal overgrowth. An impaired metabolic milieu related to increased maternal BMI as well as higher glucose levels at mid-gestation may impact fetal overgrowth in women still in the range of normal glucose tolerance.

Dataset Information

The Differential Association between Muscle Strength and Diabetes Mellitus According to the Presence or Absence of Obesity.

Publications

The Differential Association between Muscle Strength and Diabetes Mellitus According to the Presence or Absence of Obesity.

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