Ontology highlight
ABSTRACT:
SUBMITTER: Karad SN
PROVIDER: S-EPMC6485403 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Karad Somnath Narayan SN Panchal Heena H Clarke Christopher C Lewis William W Lam Hon Wai HW
Angewandte Chemie (International ed. in English) 20180619 29
The enantioselective synthesis of highly functionalized chiral cyclopent-2-enones by the reaction of alkynyl malonate esters with arylboronic acids is described. These desymmetrizing arylative cyclizations are catalyzed by a chiral phosphinooxazoline/nickel complex, and cyclization is enabled by the reversible E/Z isomerization of alkenylnickel species. The general methodology is also applicable to the synthesis of 1,6-dihydropyridin-3(2H)-ones. ...[more]