Ontology highlight
ABSTRACT:
SUBMITTER: Groessl M
PROVIDER: S-EPMC6485486 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Groessl Michael M Tsybin Yury O YO Hartinger Christian G CG Keppler Bernhard K BK Dyson Paul J PJ
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20100307 5
The binding of the ruthenium-based anticancer drug candidates KP1019, NAMI-A and RAPTA-T towards different double-stranded oligonucleotides was probed by electrospray ionisation mass spectrometry and compared with that of the widely used platinum-based chemotherapeutics cisplatin, carboplatin and oxaliplatin. It was found that the extent of adduct formation decreased in the following order: cisplatin > oxaliplatin > NAMI-A > RAPTA-T > carboplatin > KP1019. In addition to the characterisation of ...[more]