Ontology highlight
ABSTRACT:
SUBMITTER: Svensson M
PROVIDER: S-EPMC6485487 | biostudies-literature | 2008 Jan
REPOSITORIES: biostudies-literature
Svensson M M Johansson-Lindbom B B Zapata F F Jaensson E E Austenaa L M LM Blomhoff R R Agace W W WW
Mucosal immunology 20080101 1
Recent studies have highlighted a central role for intestinal dendritic cells (DCs) and vitamin A metabolite retinoic acid (RA) in the generation of alpha4beta7(+) CCR9(+)"gut tropic" effector T cells. Here, using RA-responsive element reporter mice, we demonstrate that both splenic and mesenteric lymph node (MLN) DCs enhanced retinoic acid receptor (RAR) signaling in CD8(+) T cells; however, only a subset of MLN DCs, expressing the integrin alpha-chain CD103, induced an early RAR signal that is ...[more]