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Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.

ABSTRACT: Vitamin A deficiency leads to increased susceptibility to a spectrum of infectious diseases. The studies presented dissect the intrinsic role of each of the retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of pathogen-specific CD8 T cells in vivo. The data show that RAR? is required for the expression of gut-homing receptors on CD8(+) T cells and survival of CD8(+) T cells in vitro. Furthermore, RAR? is essential for survival of CD8(+) T cells in vivo following Listeria monocytogenes infection. In contrast, RAR? deletion leads to modest deficiency in Ag-specific CD8(+) T cell expansion during infection. The defective survival of RAR?-deficient CD8(+) T cells leads to a deficiency in control of L. monocytogenes expansion in the spleen. To our knowledge, these are the first comparative studies of the role of RAR isoforms in CD8(+) T cell immunity.

SUBMITTER: Guo Y

PROVIDER: S-EPMC4648262 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Dissecting the role of retinoic acid receptor isoforms in the CD8 response to infection.

Guo Yanxia Y Lee Yu-Chi YC Brown Chrysothemis C Zhang Weijun W Usherwood Edward E Noelle Randolph J RJ

Journal of immunology (Baltimore, Md. : 1950) 20140307 7

Vitamin A deficiency leads to increased susceptibility to a spectrum of infectious diseases. The studies presented dissect the intrinsic role of each of the retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of pathogen-specific CD8 T cells in vivo. The data show that RARα is required for the expression of gut-homing receptors on CD8(+) T cells and survival of CD8(+) T cells in vitro. Furthermore, RARα is essential for survival of CD8(+) T cells in vivo ...[more]

PMID: 24610012

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