Ontology highlight
ABSTRACT:
SUBMITTER: Cheng X
PROVIDER: S-EPMC6486541 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Cheng Xiankun X Zhao Yanxiang Y Jiang Qingshan Q Yang Jun J Zhao Wensheng W Taylor Ian A IA Peng You-Liang YL Wang Dongli D Liu Junfeng J
Nucleic acids research 20190501 8
In rice, the critical regulator of the salicylic acid signalling pathway is OsWRKY45, a transcription factor (TF) of the WRKY TF family that functions by binding to the W-box of gene promoters, but the structural basis of OsWRKY45/W-box DNA recognition is unknown. Here, we show the crystal structure of the DNA binding domain of OsWRKY45 (OsWRKY45-DBD, i.e. the WRKY and zinc finger domain) in complex with a W-box DNA. Surprisingly, two OsWRKY45-DBD molecules exchange β4-β5 strands to form a dimer ...[more]