Ontology highlight
ABSTRACT:
SUBMITTER: Qi G
PROVIDER: S-EPMC6486646 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Qi Guanghao G Chatterjee Nilanjan N
Nature communications 20190426 1
Mendelian randomization (MR) has emerged as a major tool for the investigation of causal relationship among traits, utilizing results from large-scale genome-wide association studies. Bias due to horizontal pleiotropy, however, remains a major concern. We propose a novel approach for robust and efficient MR analysis using large number of genetic instruments, based on a novel spike-detection algorithm under a normal-mixture model for underlying effect-size distributions. Simulations show that the ...[more]