Ontology highlight
ABSTRACT:
SUBMITTER: Nyberg S
PROVIDER: S-EPMC6488020 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nyberg Sophie S Abbott N Joan NJ Shi Xiaorui X Steyger Peter S PS Dabdoub Alain A
Science translational medicine 20190301 482
Permanent hearing loss affects more than 5% of the world's population, yet there are no nondevice therapies that can protect or restore hearing. Delivery of therapeutics to the cochlea and vestibular system of the inner ear is complicated by their inaccessible location. Drug delivery to the inner ear via the vasculature is an attractive noninvasive strategy, yet the blood-labyrinth barrier at the luminal surface of inner ear capillaries restricts entry of most blood-borne compounds into inner ea ...[more]