Ontology highlight
ABSTRACT:
SUBMITTER: Hashemzadeh K
PROVIDER: S-EPMC6488499 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Hashemzadeh Kamelia K Jokar Mohammad Hassan MH Sedighi Sima S Moradzadeh Maliheh M
Middle East journal of digestive diseases 20181121 1
Therapeutic targeting of phosphatidyl-inositol 3-kinase (PI3K) is considered as a possible strategy in several types of cancer, including gastrointestinal ones. In vitro and in vivo studies indicated the significance of proapoptotic and antiproliferative inhibition of PI3K. Although there are many phase 1 and 2 clinical trials on PI3K inhibitors in patients with gastrointestinal cancer, the molecular mechanism of PI3K targeting PI3K/ mTOR pathway is not clear. Panclass I, isoformselective, and d ...[more]