Ontology highlight
ABSTRACT:
SUBMITTER: Lee SM
PROVIDER: S-EPMC6488615 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Lee Sun Min SM Kim Nayoung N Nam Ryoung Hee RH Park Ji Hyun JH Choi Soo In SI Park Young-Tae YT Kim Yeon-Ran YR Seok Yeong-Jae YJ Shin Cheol Min CM Lee Dong Ho DH
Scientific reports 20190429 1
The association between adverse effects of PPI and gut microbiota in old age has yet to be elucidated. We assessed changes in the gut microbiota and butyrate levels following the long-term administration of PPIs to old rats and investigated their associations. F344 aged male rats were fed a PPI-supplemented diet for 50 weeks. The ileal microbiota was analysed by metagenomic sequencing of the 16S rRNA, while the butyrate concentration was measured by high-performance liquid chromatography. We obs ...[more]