Ontology highlight
ABSTRACT:
SUBMITTER: Cavalli M
PROVIDER: S-EPMC6489362 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cavalli Marco M Baltzer Nicholas N Pan Gang G Bárcenas Walls José Ramón JR Smolinska Garbulowska Karolina K Kumar Chanchal C Skrtic Stanko S Komorowski Jan J Wadelius Claes C
Human genomics 20190429 1
<h4>Background</h4>Genome-wide association studies (GWAS) of diseases and traits have found associations to gene regions but not the functional SNP or the gene mediating the effect. Difference in gene regulatory signals can be detected using chromatin immunoprecipitation and next-gen sequencing (ChIP-seq) of transcription factors or histone modifications by aligning reads to known polymorphisms in individual genomes. The aim was to identify such regulatory elements in the human liver to understa ...[more]