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Dysregulation of miRNA and its potential therapeutic application in schizophrenia.

ABSTRACT: Although it is generally believed that genetic and developmental factors play critical roles in pathogenesis of schizophrenia, however, the precise etiological mechanism of schizophrenia remains largely unknown. Over past decades, miRNAs have emerged as an essential post-transcriptional regulator in gene expression regulation. The importance of miRNA in brain development and neuroplasticity has been well-established. Abnormal expression and dysfunction of miRNAs are known to involve in the pathophysiology of many neuropsychiatric diseases including schizophrenia. In this review, we summarized the recent findings in the schizophrenia-associated dysregulation of miRNA and functional roles in the development and pathogenesis of schizophrenia. We also discussed the potential therapeutic implications of miRNA regulation in the illness.

SUBMITTER: Cao T

PROVIDER: S-EPMC6490029 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature

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Dysregulation of miRNA and its potential therapeutic application in schizophrenia.

Cao Ting T Zhen Xue-Chu XC

CNS neuroscience & therapeutics 20180312 7

Although it is generally believed that genetic and developmental factors play critical roles in pathogenesis of schizophrenia, however, the precise etiological mechanism of schizophrenia remains largely unknown. Over past decades, miRNAs have emerged as an essential post-transcriptional regulator in gene expression regulation. The importance of miRNA in brain development and neuroplasticity has been well-established. Abnormal expression and dysfunction of miRNAs are known to involve in the patho ...[more]

PMID: 29529357

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