Ontology highlight
ABSTRACT:
SUBMITTER: Soh YS
PROVIDER: S-EPMC6491042 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Soh Yq Shirleen YS Moncla Louise H LH Eguia Rachel R Bedford Trevor T Bloom Jesse D JD
eLife 20190430
Viruses like influenza are infamous for their ability to adapt to new hosts. Retrospective studies of natural zoonoses and passaging in the lab have identified a modest number of host-adaptive mutations. However, it is unclear if these mutations represent all ways that influenza can adapt to a new host. Here we take a prospective approach to this question by completely mapping amino-acid mutations to the avian influenza virus polymerase protein PB2 that enhance growth in human cells. We identify ...[more]