Dataset Information

Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β.

ABSTRACT:

Background and aims

Emerging evidence shows that fibroblast growth factor 22 (FGF22) plays a critical role in the etiology of depression. However, the molecular mechanisms of FGF22 are not fully comprehended. Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments.

Methods

Serum from depressive patients was collected, and the levels of FGF22 and IL-1β were analyzed by ELISA. The chronic unpredictable mild stress (CUMS) model was established, and primary hippocampal neuronal cells were cultured to examine changes in FGF22 and IL-1β levels in rat hippocampus.

Results

The results revealed a negative correlation between serum FGF22 levels and serum IL-1β levels. The expression of IL-1β in the CUMS rat hippocampus decreased, and the apoptosis of hippocampal cells improved after the injection of lentiviral vector-mediated FGF22 (LV-FGF22). Further tests in primary hippocampal neuronal cells also showed a reduction in IL-1β and the cell apoptosis rate after treatment with FGF22.

Conclusion

In conclusion, the results revealed that FGF22 plays a role in alleviating depression, which may be mediated by reduced expression of IL-1β.

SUBMITTER: Xu YH

PROVIDER: S-EPMC6492756 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature

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Publications

Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β.

Xu Yu-Hao YH Yu Ming M Wei Hong H Yao Shun S Chen Si-Yuan SY Zhu Xiao-Lan XL Li Yue-Feng YF

CNS neuroscience & therapeutics 20170925 11

<h4>Background and aims</h4>Emerging evidence shows that fibroblast growth factor 22 (FGF22) plays a critical role in the etiology of depression. However, the molecular mechanisms of FGF22 are not fully comprehended. Here, the effect of FGF22 in depression and its relationship with interleukin-1β (IL-1β) were investigated in clinical, animal, and cell experiments.<h4>Methods</h4>Serum from depressive patients was collected, and the levels of FGF22 and IL-1β were analyzed by ELISA. The chronic un ...[more]

PMID: 28948716

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Dataset Information

Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β.

Background and aims

Methods

Results

Conclusion

Publications

Fibroblast growth factor 22 is a novel modulator of depression through interleukin-1β.

Similar Datasets

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