Ontology highlight
ABSTRACT:
SUBMITTER: Muraglia KA
PROVIDER: S-EPMC6492938 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Muraglia Katrina A KA Chorghade Rajeev S RS Kim Bo Ram BR Tang Xiao Xiao XX Shah Viral S VS Grillo Anthony S AS Daniels Page N PN Cioffi Alexander G AG Karp Philip H PH Zhu Lingyang L Welsh Michael J MJ Burke Martin D MD
Nature 20190313 7748
Loss-of-function mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) compromise epithelial HCO<sub>3</sub><sup>-</sup> and Cl<sup>-</sup> secretion, reduce airway surface liquid pH, and impair respiratory host defences in people with cystic fibrosis<sup>1-3</sup>. Here we report that apical addition of amphotericin B, a small molecule that forms unselective ion channels, restored HCO<sub>3</sub><sup>-</sup> secretion and increased airway surface liquid pH in cultured airw ...[more]