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The LRRK2 R1628P variant plays a protective role in Han Chinese population with Alzheimer's disease.

ABSTRACT: AIMS:Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative disorders that may share some overlapping etiologies. Mutations within leucine-rich repeat kinase 2 (LRRK2) have been reported to be responsible for PD, and the location of LRRK2 is within a linkage peak for sporadic AD (SAD). The aim of this study was to investigate two Asian-specific LRRK2 variants, R1628P and G2385R, with the association of Han Chinese SAD. METHODS:Genotyping of R1628P and G2385R was performed by PCR-restriction fragment length polymorphism (RFLP) analysis in 390 patients with SAD and 545 unrelated age- and sex-matched healthy controls. RESULTS:The frequency of the C allele within R1628P was more than three times higher in control group (1.7%) than in patients with SAD (0.5%) (OR 0.264; 95% CI, 0.088-0.792, P = 0.018). After stratification by the presence of one or two apolipoprotein E ?4 alleles, the protective effect becomes stronger (?44: OR 0.028; 95% CI, 0.003-0.303, P = 0.003; ?4: OR 0.104; 95% CI, 0.013-0.818, P = 0.031). However, no difference was found in G2385R variant. CONCLUSION:Our study suggested that R1628P variant within LRRK2 plays a protective role in Han Chinese population with SAD and such effect has an interaction with the APOE genotype.

SUBMITTER: Li HL

PROVIDER: S-EPMC6493338 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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The LRRK2 R1628P variant plays a protective role in Han Chinese population with Alzheimer's disease.

Li Hong-Lei HL Lu Shen-Ji SJ Sun Yi-Min YM Guo Qi-Hao QH Sadovnick Adele Dessa AD Wu Zhi-Ying ZY

CNS neuroscience & therapeutics 20130220 4

<h4>Aims</h4>Alzheimer's disease (AD) and Parkinson's disease (PD) are the most prevalent neurodegenerative disorders that may share some overlapping etiologies. Mutations within leucine-rich repeat kinase 2 (LRRK2) have been reported to be responsible for PD, and the location of LRRK2 is within a linkage peak for sporadic AD (SAD). The aim of this study was to investigate two Asian-specific LRRK2 variants, R1628P and G2385R, with the association of Han Chinese SAD.<h4>Methods</h4>Genotyping of ...[more]

PMID: 23421816

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Dataset Information

The LRRK2 R1628P variant plays a protective role in Han Chinese population with Alzheimer's disease.

Publications

The LRRK2 R1628P variant plays a protective role in Han Chinese population with Alzheimer's disease.

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