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Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases.

ABSTRACT: The ATP-sensitive K+ (KATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic ? cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K+ channel subtypes in physiological and pathological processes in a variety of cardiovascular diseases. In this review, we focus on the causal relationship between ATP-sensitive K+ channel activity and pathophysiology in the cardiovascular system, particularly from the perspective of genetic changes in human and animal models.

SUBMITTER: Huang Y

PROVIDER: S-EPMC6494091 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases.

Huang Yan Y Hu Dan D Huang Congxin C Nichols Colin G CG

Circulation. Arrhythmia and electrophysiology 20190501 5

The ATP-sensitive K+ (KATP) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K+ channel subtypes in physiological and patholo ...[more]

PMID: 31030551

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