Genetic Discovery of ATP-Sensitive K+ Channels in Cardiovascular Diseases.
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ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC6494091 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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Genetic Discovery of ATP-Sensitive K<sup>+</sup> Channels in Cardiovascular Diseases.
Huang Yan Y Hu Dan D Huang Congxin C Nichols Colin G CG
Circulation. Arrhythmia and electrophysiology 20190501 5
The ATP-sensitive K<sup>+</sup> (K<sub>ATP</sub>) channels are hetero-octameric protein complexes comprising 4 pore-forming (Kir6.x) subunits and 4 regulatory sulfonylurea receptor (SURx) subunits. They are prominent in myocytes, pancreatic β cells, and neurons and link cellular metabolism with membrane excitability. Using genetically modified animals and genomic analysis in patients, recent studies have implicated certain ATP-sensitive K<sup>+</sup> channel subtypes in physiological and patholo ...[more]
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