Unknown

Dataset Information

0

68Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis.


ABSTRACT: Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, 68Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of 68Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linearly correlated ( R2 = 0.98) with the concentration of lung allysine.

SUBMITTER: Wahsner J 

PROVIDER: S-EPMC6494104 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

<sup>68</sup>Ga-NODAGA-Indole: An Allysine-Reactive Positron Emission Tomography Probe for Molecular Imaging of Pulmonary Fibrogenesis.

Wahsner Jessica J   Désogère Pauline P   Abston Eric E   Graham-O'Regan Katherine A KA   Wang Junfeng J   Rotile Nicholas J NJ   Schirmer Markus D MD   Santos Ferreira Diêgo Dos DD   Sui Jingyi J   Fuchs Bryan C BC   Lanuti Michael M   Caravan Peter P  

Journal of the American Chemical Society 20190327 14


Oxidized collagen, wherein lysine residues are converted to the aldehyde allysine, is a universal feature of fibrogenesis, i.e. actively progressive fibrosis. Here we report the small molecule, allysine-binding positron emission tomography probe, <sup>68</sup>Ga-NODAGA-indole, that can noninvasively detect and quantify pulmonary fibrogenesis. We demonstrate that the uptake of <sup>68</sup>Ga-NODAGA-indole in actively fibrotic lungs is 7-fold higher than in control groups and that uptake is linea  ...[more]

Similar Datasets

| S-EPMC7179119 | biostudies-literature
2015-02-09 | E-MTAB-3175 | biostudies-arrayexpress
2011-11-01 | GSE21217 | GEO
| S-EPMC4287963 | biostudies-literature
2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
2020-03-18 | GSE131769 | GEO
| S-EPMC6621018 | biostudies-literature
| S-EPMC2678789 | biostudies-other
| S-EPMC9856704 | biostudies-literature
| S-EPMC5411699 | biostudies-literature