Ontology highlight
ABSTRACT:
SUBMITTER: Saffouri GB
PROVIDER: S-EPMC6494866 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Saffouri George B GB Shields-Cutler Robin R RR Chen Jun J Yang Yi Y Lekatz Heather R HR Hale Vanessa L VL Cho Janice M JM Battaglioli Eric J EJ Bhattarai Yogesh Y Thompson Kevin J KJ Kalari Krishna K KK Behera Gaurav G Berry Jonathan C JC Peters Stephanie A SA Patel Robin R Schuetz Audrey N AN Faith Jeremiah J JJ Camilleri Michael M Sonnenburg Justin L JL Farrugia Gianrico G Swann Jonathan R JR Grover Madhusudan M Knights Dan D Kashyap Purna C PC
Nature communications 20190501 1
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an overgrowth of anaerobes, does not correspond with patient symptoms, and may be a result of dietary preferences. Small intestinal microbial composition, on the other hand, is significantly altered in sy ...[more]