Dataset Information
Influenza Vaccine Effectiveness and Statin Use Among Adults in the United States, 2011-2017.
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ABSTRACT: Background
Statin medications have immunomodulatory effects. Several recent studies suggest that statins may reduce influenza vaccine response and reduce influenza vaccine effectiveness (VE).Methods
We compared influenza VE in statin users and nonusers aged ?45 years enrolled in the US Vaccine Effectiveness Network study over 6 influenza seasons (2011-2012 through 2016-2017). All enrollees presented to outpatients clinics with acute respiratory illness and were tested for influenza. Information on vaccination status, medical history, and statin use at the time of vaccination were collected by medical and pharmacy records. Using a test-negative design, we estimated VE as (1 - OR) × 100, in which OR is the odds ratio for testing positive for influenza virus among vaccinated vs unvaccinated participants.Results
Among 11692 eligible participants, 3359 (30%) were statin users and 2806 (24%) tested positive for influenza virus infection; 78% of statin users and 60% of nonusers had received influenza vaccine. After adjusting for potential confounders, influenza VE was 36% (95% confidence interval [CI], 22%-47%) among statin users and 39% (95% CI, 32%-45%) among nonusers. We observed no significant modification of VE by statin use. VE against influenza A(H1N1)pdm09, A(H3N2), and B viruses were similar among statin users and nonusers.Conclusions
In this large observational study, influenza VE against laboratory-confirmed influenza illness was not affected by current statin use among persons aged ?45 years. Statin use did not modify the effect of vaccination on influenza when analyzed by type and subtype.
SUBMITTER: Havers FP
PROVIDER: S-EPMC6495015 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Publications
Influenza Vaccine Effectiveness and Statin Use Among Adults in the United States, 2011-2017.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20190501 10
<h4>Background</h4>Statin medications have immunomodulatory effects. Several recent studies suggest that statins may reduce influenza vaccine response and reduce influenza vaccine effectiveness (VE).<h4>Methods</h4>We compared influenza VE in statin users and nonusers aged ≥45 years enrolled in the US Vaccine Effectiveness Network study over 6 influenza seasons (2011-2012 through 2016-2017). All enrollees presented to outpatients clinics with acute respiratory illness and were tested for influen ...[more]