Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury.
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ABSTRACT:
SUBMITTER: Dolle JP
PROVIDER: S-EPMC6495524 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Newfound sex differences in axonal structure underlie differential outcomes from in vitro traumatic axonal injury.
Dollé Jean-Pierre JP Jaye Andrew A Anderson Stewart A SA Ahmadzadeh Hossein H Shenoy Vivek B VB Smith Douglas H DH
Experimental neurology 20171122
Since traumatic axonal injury (TAI) is implicated as a prominent pathology of concussion, we examined potential sex differences in axon structure and responses to TAI. Rat and human neurons were used to develop micropatterned axon tracts in vitro that were genetically either male or female. Ultrastructural analysis revealed for the first time that female axons were consistently smaller with fewer microtubules than male axons. Computational modeling of TAI showed that these structural differences ...[more]
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