Ontology highlight
ABSTRACT:
SUBMITTER: Ide S
PROVIDER: S-EPMC9795409 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Ide Shintaro S Ide Kana K Abe Koki K Kobayashi Yoshihiko Y Kitai Hiroki H McKey Jennifer J Strausser Sarah A SA O'Brien Lori L LL Tata Aleksandra A Tata Purushothama Rao PR Souma Tomokazu T
Cell reports 20221101 6
In both humans and mice, repair of acute kidney injury is worse in males than in females. Here, we provide evidence that this sexual dimorphism results from sex differences in ferroptosis, an iron-dependent, lipid-peroxidation-driven regulated cell death. Using genetic and single-cell transcriptomic approaches in mice, we report that female sex confers striking protection against ferroptosis, which was experimentally induced in proximal tubular (PT) cells by deleting glutathione peroxidase 4 (Gp ...[more]