Unknown

Dataset Information

0

A novel type II membrane receptor up-regulated by IFN-alpha in fibroblasts functions in cell proliferation through the JAK-STAT signalling pathway.

ABSTRACT: A type II membrane protein similar to CD69 (TIIMPSC) has been isolated in human embryo fibroblasts treated with IFN-alpha. Structural analysis and immunofluorescence detection has suggested that this protein is located on the surface of fibroblasts, generally considered, a receptor. Cell proliferation assay has revealed that activation of TIIMPSC elevates the level of fibroblast proliferation. Further, examination of signal transduction has indicated that expression of this protein is up-regulated by IFN-alpha stimulation, and that it is involved in the regulation of fibroblast growth through the JAK-STAT signalling pathway.

SUBMITTER: Liu LD 

PROVIDER: S-EPMC6496284 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A novel type II membrane receptor up-regulated by IFN-alpha in fibroblasts functions in cell proliferation through the JAK-STAT signalling pathway.

Liu L-D LD   Dong C-H CH   Shi H-J HJ   Zhao H-L HL   Wang L-C LC   Ma S-H SH   Li Q-H QH  

Cell proliferation 20060401 2

A type II membrane protein similar to CD69 (TIIMPSC) has been isolated in human embryo fibroblasts treated with IFN-alpha. Structural analysis and immunofluorescence detection has suggested that this protein is located on the surface of fibroblasts, generally considered, a receptor. Cell proliferation assay has revealed that activation of TIIMPSC elevates the level of fibroblast proliferation. Further, examination of signal transduction has indicated that expression of this protein is up-regulat  ...[more]

Similar Datasets

Unknown Pegylated IFN-α regulates hepatic gene expression through transient Jak/STAT activation.
| S-EPMC3973080 | biostudies-literature
Unknown IGF2BP3 facilitates cell proliferation and tumorigenesis via modulation of JAK/STAT signalling pathway in human bladder cancer.
| S-EPMC7753985 | biostudies-literature
Unknown JAK-STAT signalling and the atrial fibrillation promoting fibrotic substrate.
| S-EPMC5852635 | biostudies-literature
Unknown IFN-?3 inhibits HIV infection of macrophages through the JAK-STAT pathway.
| S-EPMC3338759 | biostudies-other
Unknown Negative regulation of Drosophila JAK-STAT signalling by endocytic trafficking.
| S-EPMC2951467 | biostudies-other
Transcriptomics Regulation of interferon-inducible proteins by doxorubicin via IFN-alpha-JAK-STAT signaling in tumor cells
2012-05-22 | E-GEOD-30988 | biostudies-arrayexpress
Unknown Narrative-based computational modelling of the Gp130/JAK/STAT signalling pathway.
| S-EPMC2678071 | biostudies-literature
Unknown Blocking Jak/STAT signalling using tofacitinib inhibits angiogenesis in experimental arthritis.
| S-EPMC8364029 | biostudies-literature
Unknown Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.
| S-EPMC1219691 | biostudies-other
Unknown Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling.
| S-EPMC6338669 | biostudies-other