A novel type II membrane receptor up-regulated by IFN-alpha in fibroblasts functions in cell proliferation through the JAK-STAT signalling pathway.
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ABSTRACT:
SUBMITTER: Liu LD
PROVIDER: S-EPMC6496284 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
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A novel type II membrane receptor up-regulated by IFN-alpha in fibroblasts functions in cell proliferation through the JAK-STAT signalling pathway.
Liu L-D LD Dong C-H CH Shi H-J HJ Zhao H-L HL Wang L-C LC Ma S-H SH Li Q-H QH
Cell proliferation 20060401 2
A type II membrane protein similar to CD69 (TIIMPSC) has been isolated in human embryo fibroblasts treated with IFN-alpha. Structural analysis and immunofluorescence detection has suggested that this protein is located on the surface of fibroblasts, generally considered, a receptor. Cell proliferation assay has revealed that activation of TIIMPSC elevates the level of fibroblast proliferation. Further, examination of signal transduction has indicated that expression of this protein is up-regulat ...[more]
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