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Incidence of dementia after age 90 in a multiracial cohort.


ABSTRACT: INTRODUCTION:Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence. METHODS:Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ?90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox proportional hazards models and Fine and Gray competing risk of death models adjusted for demographics and comorbidities in midlife and late-life. RESULTS:Dementia incidence rates (n = 771 cases) were lowest among Asians (89.9/1000 person-years), followed by whites (96.9/1000 person-years), Latinos (105.8/1000 person-years), and blacks (121.5/1000 person-years). Cox regression and competing risk models estimated 28% and 36% higher dementia risk for blacks versus whites adjusting for demographics and comorbidities. DISCUSSION:Patterns of racial/ethnic disparities in dementia seen in younger older adults continue after the age of 90 years, though smaller in magnitude.

SUBMITTER: Gilsanz P 

PROVIDER: S-EPMC6497045 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Incidence of dementia after age 90 in a multiracial cohort.

Gilsanz Paola P   Corrada Maria M MM   Kawas Claudia H CH   Mayeda Elizabeth Rose ER   Glymour M Maria MM   Quesenberry Charles P CP   Lee Catherine C   Whitmer Rachel A RA  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20190220 4


<h4>Introduction</h4>Little is known about dementia incidence in diverse populations of oldest-old, the age group with highest dementia incidence.<h4>Methods</h4>Incident dementia diagnoses from 1/1/2010 to 9/30/2015 were abstracted from medical records for 2350 members of an integrated health care system in California (n = 1702 whites, n = 375 blacks, n = 105 Latinos, n = 168 Asians) aged ≥90 in 2010. We estimated race/ethnicity-specific age-adjusted dementia incidence rates and implemented Cox  ...[more]

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