Ontology highlight
ABSTRACT:
SUBMITTER: Kwak MJ
PROVIDER: S-EPMC6497169 | biostudies-literature | 2017 Jul
REPOSITORIES: biostudies-literature
Kwak Mi-Jeong MJ Kim J Dongun JD Kim Hyunmin H Kim Cheolhee C Bowman James W JW Kim Seonghoon S Joo Keehyoung K Lee Jooyoung J Jin Kyeong Sik KS Kim Yeon-Gil YG Lee Nam Ki NK Jung Jae U JU Oh Byung-Ha BH
Nature microbiology 20170717
Many bacteria, including Legionella pneumophila, rely on the type IV secretion system to translocate a repertoire of effector proteins into the hosts for their survival and growth. Type IV coupling protein (T4CP) is a hexameric ATPase that links translocating substrates to the transenvelope secretion conduit. Yet, how a large number of effector proteins are selectively recruited and processed by T4CPs remains enigmatic. DotL, the T4CP of L. pneumophila, contains an ATPase domain and a C-terminal ...[more]