Ontology highlight
ABSTRACT:
SUBMITTER: Fontebasso Y
PROVIDER: S-EPMC6497172 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Fontebasso Yari Y Dubinett Steven M SM
Critical reviews in oncogenesis 20150101 5-6
Metastatic disease is responsible for 90% of death from solid tumors. However, only a minority of metastasis-specific targets has been exploited therapeutically, and effective prevention and suppression of metastatic disease is still an elusive goal. In this review, we will first summarize the current state of knowledge about the molecular features of the disease, with particular focus on steps and targets potentially amenable to therapeutic intervention. We will then discuss the reasons underly ...[more]