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Ruthenium-Catalyzed Redox Isomerizations inside Living Cells.

ABSTRACT: Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the "in cellulo" generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate the compatibility of organometallic mechanisms with the complex environment of cells.

SUBMITTER: Vidal C

PROVIDER: S-EPMC6497367 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Ruthenium-Catalyzed Redox Isomerizations inside Living Cells.

Vidal Cristian C Tomás-Gamasa María M Gutiérrez-González Alejandro A Mascareñas José L JL

Journal of the American Chemical Society 20190322 13

Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the "in cellulo" generation of fluorescent and bioactive probes. Overall, our research reveals a novel metal-based tool for cellular intervention, and comes to further demonstrate ...[more]

PMID: 30892889

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