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Immunoprofiling of Colitis-associated and Sporadic Colorectal Cancer and its Clinical Significance.


ABSTRACT: Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple immune markers, is a novel method for examining the tumor immune environment. We compared the expression levels of various surface markers in immune cells between colitis-associated cancer (CAC) and sporadic colorectal cancer (CRC) and evaluated the clinical usefulness of immunoprofiling in CRC. Tumor specimens from 24 CAC patients and 48 sporadic CRC patients, matched by age, sex, and tumor location to CAC, were included in the analysis. The expression levels of CD3, CD8, Foxp3, and programmed death-ligand 1 (PD-L1) in immune cells at the invasive margins of tumor tissues were evaluated by quantitative multispectral imaging. The CAC group had significantly less levels of cells expressing CD3, CD8, Foxp3, or PD-L1 (all, p?

SUBMITTER: Soh JS 

PROVIDER: S-EPMC6497720 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Immunoprofiling of Colitis-associated and Sporadic Colorectal Cancer and its Clinical Significance.

Soh Jae Seung JS   Jo Su In SI   Lee Hyejin H   Do Eun-Ju EJ   Hwang Sung Wook SW   Park Sang Hyoung SH   Ye Byong Duk BD   Byeon Jeong-Sik JS   Yang Suk-Kyun SK   Kim Ji Hun JH   Yang Dong-Hoon DH   Kim Sang-Yeob SY   Myung Seung-Jae SJ  

Scientific reports 20190502 1


Immunoprofiling is useful for predicting prognosis in various malignancies and provides targets for immunotherapy. Quantitative multispectral imaging system, which allows simultaneous detection of multiple immune markers, is a novel method for examining the tumor immune environment. We compared the expression levels of various surface markers in immune cells between colitis-associated cancer (CAC) and sporadic colorectal cancer (CRC) and evaluated the clinical usefulness of immunoprofiling in CR  ...[more]

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