The role of nicotinic receptor genes (CHRN) in the pathways of prenatal tobacco exposure on smoking behavior among young adult light smokers.

ABSTRACT: BACKGROUND:Prenatal tobacco exposure (PTE) is associated with more frequent smoking among young, light smokers. Little is known about how nicotinic acetylcholine receptor (CHRN) genes may contribute to this relationship. METHODS:Data were drawn from a longitudinal cohort of young light smokers of European ancestry (N?=?511). Three single nucleotide polymorphisms (SNPs) among offspring, rs16969968 and rs6495308 in CHRNA5A3B4 and rs2304297 in CHRNB3A6, were analyzed with respect to whether they 1) predict PTE status; 2) confound the previously-reported effects of PTE on future smoking; 3) have effects on youth smoking frequency that are mediated through PTE; and 4) have effects that are moderated by PTE. RESULTS:rs2304297 and rs6495308 were associated with increased likelihood and severity of PTE, respectively. In a path analysis, rs16969968 directly predicted more frequent smoking in young adulthood (B?=?1.50, p?=?.044); this association was independent of, and not mediated by, PTE. The risk of rs16969968 (IRR?=?1.07, p?=?.015) and the protective effect of rs2304297 (IRR?=?0.84, p?

SUBMITTER: Selya AS 

PROVIDER: S-EPMC6499075 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature