Dataset Information

Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony.

ABSTRACT: Baboons (genus Papio) are broadly studied in the wild and in captivity. They are widely used as a nonhuman primate model for biomedical studies, and the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute has maintained a large captive baboon colony for more than 50 yr. Unlike other model organisms, however, the genomic resources for baboons are severely lacking. This has hindered the progress of studies using baboons as a model for basic biology or human disease. Here, we describe a data set of 100 high-coverage whole-genome sequences obtained from the mixed colony of olive (P. anubis) and yellow (P. cynocephalus) baboons housed at the SNPRC. These data provide a comprehensive catalog of common genetic variation in baboons, as well as a fine-scale genetic map. We show how the data can be used to learn about ancestry and admixture and to correct errors in the colony records. Finally, we investigated the consequences of inbreeding within the SNPRC colony and found clear evidence for increased rates of infant mortality and increased homozygosity of putatively deleterious alleles in inbred individuals.

SUBMITTER: Robinson JA

PROVIDER: S-EPMC6499309 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony.

Robinson Jacqueline A JA Belsare Saurabh S Birnbaum Shifra S Newman Deborah E DE Chan Jeannie J Glenn Jeremy P JP Ferguson Betsy B Cox Laura A LA Wall Jeffrey D JD

Genome research 20190329 5

Baboons (genus <i>Papio</i>) are broadly studied in the wild and in captivity. They are widely used as a nonhuman primate model for biomedical studies, and the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute has maintained a large captive baboon colony for more than 50 yr. Unlike other model organisms, however, the genomic resources for baboons are severely lacking. This has hindered the progress of studies using baboons as a model for basic biology or h ...[more]

PMID: 30926611

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Dataset Information

Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony.

Publications

Analysis of 100 high-coverage genomes from a pedigreed captive baboon colony.

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