Ontology highlight
ABSTRACT:
SUBMITTER: Palangat M
PROVIDER: S-EPMC6499322 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Genes & development 20190306 9-10
Somatic mutations in the genes encoding components of the spliceosome occur frequently in human neoplasms, including myeloid dysplasias and leukemias, and less often in solid tumors. One of the affected factors, U2AF1, is involved in splice site selection, and the most common change, S34F, alters a conserved nucleic acid-binding domain, recognition of the 3' splice site, and alternative splicing of many mRNAs. However, the role that this mutation plays in oncogenesis is still unknown. Here, we u ...[more]