Ontology highlight
ABSTRACT:
SUBMITTER: Danielson ND
PROVIDER: S-EPMC6499371 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Danielson Noah D ND Collins James J Stothard Alicyn I AI Dong Qing Qing QQ Kalera Karishma K Woodruff Peter J PJ DeBosch Brian J BJ Britton Robert A RA Swarts Benjamin M BM
Chemical communications (Cambridge, England) 20190401 34
Trehalose is used as an additive in thousands of foods, cosmetics, and pharmaceutical products, and it is being investigated as a therapeutic for multiple human diseases. However, its ability to be used as a carbon source by microbes is a concern, as highlighted by the recent finding that trehalose can be metabolized by and potentially enhance the virulence of epidemic Clostridioides difficile. Here, we show that trehalose analogues designed to resist enzymatic degradation are incapable of being ...[more]