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High spatial resolution scintillator dosimetry of synchrotron microbeams.

ABSTRACT: Microbeam radiation therapy is a novel pre-clinical external beam therapy that uses high-brilliance synchrotron X-rays to deliver the necessary high dose rates. The unique conditions of high dose rate and high spatial fractionation demand a new class of detector to experimentally measure important beam quality parameters. Here we demonstrate the highest spatial resolution plastic scintillator fibre-optic dosimeter found in the literature to date and tested it on the Imaging and Medical Beam-Line at the Australian Synchrotron in a X-ray beam where the irradiation dose rate was 4435?Gy/s. With a one-dimensional spatial resolution of 10??m the detector is able to resolve the individual microbeams (53.7?±?0.4??m wide), and measure the peak-to-valley dose ratio to be 55?±?17. We also investigate the role of radioluminescence in the optical fibre used to transport the scintillation photons, and conclude that it creates a significant contribution to the total light detected.

SUBMITTER: Archer J

PROVIDER: S-EPMC6499773 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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High spatial resolution scintillator dosimetry of synchrotron microbeams.

Archer James J Li Enbang E Davis Jeremy J Cameron Matthew M Rosenfeld Anatoly A Lerch Michael M

Scientific reports 20190503 1

Microbeam radiation therapy is a novel pre-clinical external beam therapy that uses high-brilliance synchrotron X-rays to deliver the necessary high dose rates. The unique conditions of high dose rate and high spatial fractionation demand a new class of detector to experimentally measure important beam quality parameters. Here we demonstrate the highest spatial resolution plastic scintillator fibre-optic dosimeter found in the literature to date and tested it on the Imaging and Medical Beam-Line ...[more]

PMID: 31053762

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Project description:PurposeThe goal of this work is to produce a surface-dosimetry method capable of accurately and remotely measuring skin dose for patients undergoing total skin electron therapy (TSET) without the need for postexposure dosimeter processing. A rapid and wireless surface-dosimetry system was developed to improve clinical workflow. Scintillator-surface dosimetry was conducted on patients undergoing TSET by imaging scintillator targets with an intensified camera during TSET delivery.Methods and materialsDisc-shaped scintillator targets were attached to the skin surface of patients undergoing TSET and imaged with an intensified, time-gated, and linear accelerator-synchronized camera. Optically stimulated luminescence dosimeters (OSLDs) were placed directly adjacent to scintillators at several dosimetry sites to serve as an absolute dose reference. Real-time image-processing methods were used to produce background-subtracted intensity maps of Cherenkov and scintillation emission. Rapid conversion of scintillator-light output to dose was achieved by using a custom fitting algorithm and calibration factor. Surface doses measured by scintillators were compared with those from OSLDs.ResultsAbsolute surface-dose measurements for 99 dosimetry sites were evaluated. According to paired OSLD estimates, scintillator dosimeters were able to report dose with <3% difference in 88 of 99 observed dosimetry sites and <5% difference in 98 of 99 observed dosimetry sites. Fitting a linear regression to dose data reported by scintillator versus OSLD, per dosimetry site, yielded an R2 = 0.94.ConclusionsScintillators were able to report dose within <3% accuracy of OSLDs. Imaging of calibrated scintillator targets via an intensified, linear accelerator-synchronized camera provides rapid absolute surface-dosimetry measurements for patients treated with TSET. This technique has the potential to reduce the amount of time and effort necessary to conduct full-body dosimetry and can be adopted for use in any surface-dosimetry setting where the region of interest is observable throughout treatment.

Dataset Information

High spatial resolution scintillator dosimetry of synchrotron microbeams.

Publications

High spatial resolution scintillator dosimetry of synchrotron microbeams.

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