Dataset Information

Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry.

ABSTRACT:

Objectives

This analysis examined the association between psoriasis severity, assessed by body surface area (BSA) and the Investigator's Global Assessment (IGA; previously used only in clinical trials), and patient-reported outcomes (PROs) in a real-world setting.

Design

Cross-sectional analysis within the Corrona Psoriasis Registry, an independent, prospective registry.

Setting

70 dermatology practices in the USA.

Participants

1529 adult patients with psoriasis being treated with biological or non-biological systemic psoriasis treatment by 31 May 2016.

Primary and secondary outcome measures

Psoriasis severity was assessed by percentage of affected BSA (mild (0%-5%), moderate (>5%-10%), severe (>10%-15%), very severe (>15%)) and IGA scores (clear/almost clear (0-1), mild (2), moderate (3), severe (4)). PROs (pain, itch, fatigue; Dermatology Life Quality Index [DLQI]; EuroQoL Visual Analogue Scale [EQ-VAS]; Work Productivity and Activity Impairment [WPAI]) were compared across BSA and IGA levels using analysis of variance and X² tests. The association between psoriasis severity and PROs was examined using multivariable regression models.

Results

The mean age was 50.6 years and 47% of patients were female. Consistently with more severe psoriasis, symptoms worsened, DLQI scores increased (p<0.05 for each level of BSA and IGA), EQ-VAS decreased (p<0.05 for each level of BSA and IGA) and WPAI scores increased. By BSA score, moderate to very severe psoriasis was associated with poorer outcomes for the 'impairment while working' and 'daily activities impaired' WPAI domains (all p<0.05 vs mild psoriasis). Very severe psoriasis was associated with increased 'work hours missed' and 'work hours affected' (both p<0.05 vs mild psoriasis) Findings were similar by IGA. Results were confirmed by multivariable regression analyses.

Conclusions

In a real-world setting, more severe psoriasis, assessed by BSA and IGA, was consistently associated with worse PROs.

SUBMITTER: Strober B

PROVIDER: S-EPMC6500315 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry.

Strober Bruce B Greenberg Jeffrey D JD Karki Chitra C Mason Marc M Guo Ning N Hur Peter P Zhao Yang Y Herrera Vivian V Lin Feng F Lebwohl Mark M

BMJ open 20190420 4

<h4>Objectives</h4>This analysis examined the association between psoriasis severity, assessed by body surface area (BSA) and the Investigator's Global Assessment (IGA; previously used only in clinical trials), and patient-reported outcomes (PROs) in a real-world setting.<h4>Design</h4>Cross-sectional analysis within the Corrona Psoriasis Registry, an independent, prospective registry.<h4>Setting</h4>70 dermatology practices in the USA.<h4>Participants</h4>1529 adult patients with psoriasis bein ...[more]

PMID: 31005939

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Dataset Information

Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry.

Objectives

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusions

Publications

Impact of psoriasis severity on patient-reported clinical symptoms, health-related quality of life and work productivity among US patients: real-world data from the Corrona Psoriasis Registry.

Similar Datasets

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