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Predictors of Long-Term Survival among High-Grade Serous Ovarian Cancer Patients.

ABSTRACT: BACKGROUND:Relatively little is known about factors associated with long-term survival (LTS) following a diagnosis of ovarian cancer. METHODS:We conducted a retrospective study of high-grade serous ovarian cancer (HGSOC) to explore predictors of LTS (defined as ?7 years of survival) using electronic medical record data from a network of integrated health care systems. Multivariable logistic regression with forward selection was used to compare characteristics of women who survived ?7 years after diagnosis (n = 148) to those who died within 7 years of diagnosis (n = 494). RESULTS:Our final model included study site, age, stage at diagnosis, CA-125, comorbidity score, receipt of chemotherapy, BMI, and four separate comorbid conditions: weight loss, depression, hypothyroidism, and liver disease. Of these, only younger age, lower stage, and depression were statistically significantly associated with LTS. CONCLUSIONS:We did not identify any new characteristics associated with HGSOC survival. IMPACT:Prognosis of ovarian cancer generally remains poor. Large, pooled studies of ovarian cancer are needed to identify characteristics that may improve survival.

SUBMITTER: Clarke CL

PROVIDER: S-EPMC6500478 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Predictors of Long-Term Survival among High-Grade Serous Ovarian Cancer Patients.

Clarke Christina L CL Kushi Lawrence H LH Chubak Jessica J Pawloski Pamala A PA Bulkley Joanna E JE Epstein Mara M MM Burnett-Hartman Andrea N AN Powell Bethan B Pearce Celeste L CL Spencer Feigelson Heather H

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20190409 5

<h4>Background</h4>Relatively little is known about factors associated with long-term survival (LTS) following a diagnosis of ovarian cancer.<h4>Methods</h4>We conducted a retrospective study of high-grade serous ovarian cancer (HGSOC) to explore predictors of LTS (defined as ≥7 years of survival) using electronic medical record data from a network of integrated health care systems. Multivariable logistic regression with forward selection was used to compare characteristics of women who survived ...[more]

PMID: 30967418

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Project description:ObjectiveWe aimed to evaluate the prognostic and predictive value of the nucleotide excision repair-related gene GTF2H5, which is localized at the 6q24.2-26 deletion previously reported by our group to predict longer survival of high-grade serous ovarian cancer patients.MethodsIn order to test if protein levels of GTF2H5 are associated with patients' outcome, we performed GTF2H5 immunohistochemical staining in 139 high-grade serous ovarian carcinomas included in tissue microarrays. Upon stratification of cases into high- and low-GTF2H5 staining categories (> and ≤ median staining, respectively) Kaplan-Meier and log-rank test were used to estimate patients' survival and assess statistical differences. We also evaluated the association of GTF2H5 with survival at the transcriptional level by using the on-line Kaplan-Meier plotter tool, which includes gene expression and survival data of 855 high-grade serous ovarian cancer patients from 13 different datasets. Finally, we determined whether stable short hairpin RNA-mediated GTF2H5 downregulation modulates cisplatin sensitivity in the SKOV3 and COV504 cell lines by using cytotoxicity assays.ResultsLow expression of GTF2H5 was associated with longer 5-year survival of patients at the protein (hazard ratio [HR], 0.52; 95% CI, 0.29 to 0.93; p=0.024) and transcriptional level (HR, 0.80; 95% CI, 0.65 to 0.97; p=0.023) in high-grade serous ovarian cancer patients. We confirmed the association with 5-year overall survival (HR, 0.55; 95% CI, 0.38 to 0.78; p=0.0007) and also found an association with progression-free survival (HR, 0.72; 95% CI, 0.54 to 0.96; p=0.026) in a homogenous group of 388 high-stage (stages III-IV using the International Federation of Gynecology and Obstetrics staging system), optimally debulked high-grade serous ovarian cancer patients. GTF2H5-silencing induced a decrease of the half maximal inhibitory concentration upon cisplatin treatment in GTF2H5-silenced ovarian cancer cells.ConclusionLow levels of GTF2H5 are associated with enhanced prognosis in high-grade serous ovarian cancer patients and may contribute to cisplatin sensitization.

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Predictors of Long-Term Survival among High-Grade Serous Ovarian Cancer Patients.

Publications

Predictors of Long-Term Survival among High-Grade Serous Ovarian Cancer Patients.

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