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[Advances of the Correlation between Driver Gene Status and Immunotherapy ?in Non-small Cell Lung Cancer].


ABSTRACT: In recent years, the checkpoint inhibitors targeted programmed cell death 1 (PD-1) and its ligand 1 (PD-1 ligand, PD-L1) achieved landmark significance in treating a variety of cancers including non-small cell lung cancer (NSCLC). However, current immunotherapy is not precise enough, only 15%-20% of the unselected patients can benefit from the therapy, and there is a possibility of hyperprogression (HP). Therefore, how to select the dominant population is crucial. Although many studies have emphasized the importance of PD-L1 and tumor mutation burden (TMB) and other indicators to guide immunotherapy, current PD-L1 expression level and mutation load cannot be used as a decisive and excluded predictive marker based on various obstacles. With the deepening of research, we found that there is a close relationship between lung cancer-driver gene mutation and aberrant activation of PD-1/PD-L1 signal pathways, and the correlation between gene mutation and immunotherapy efficacy has broad research value. This article will revolve around the above issues.?.

SUBMITTER: Chen J 

PROVIDER: S-EPMC6500499 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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[Advances of the Correlation between Driver Gene Status and Immunotherapy 
in Non-small Cell Lung Cancer].

Chen Jie J   Jiang Da D   Huang Fang F  

Zhongguo fei ai za zhi = Chinese journal of lung cancer 20190401 4


In recent years, the checkpoint inhibitors targeted programmed cell death 1 (PD-1) and its ligand 1 (PD-1 ligand, PD-L1) achieved landmark significance in treating a variety of cancers including non-small cell lung cancer (NSCLC). However, current immunotherapy is not precise enough, only 15%-20% of the unselected patients can benefit from the therapy, and there is a possibility of hyperprogression (HP). Therefore, how to select the dominant population is crucial. Although many studies have emph  ...[more]

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