Optimization of Resolving Power, Fragmentation, and Mass Calibration in an Orbitrap Spectrometer for Analysis of 24 Pesticide Metabolites in Urine.
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ABSTRACT:
SUBMITTER: Dualde P
PROVIDER: S-EPMC6500652 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Optimization of Resolving Power, Fragmentation, and Mass Calibration in an Orbitrap Spectrometer for Analysis of 24 Pesticide Metabolites in Urine.
Dualde Pablo P Coscollà Clara C Pastor Agustin A Yusà Vicent V
International journal of analytical chemistry 20190417
Mass spectrometer parameters such as Resolving Power, type of fragmentation, and mass calibration mode were optimized in the analysis of 24 pesticide metabolites in human urine using Ultra-High Pressure Liquid Chromatography coupled to Orbitrap High-Resolution Mass Spectrometer (UHPLC-HRMS). The best results were achieved with a Resolving Power of 25,000 FWHM and by applying Collision Induced Dissociation fragmentation mode (40 eV). ...[more]
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