Ontology highlight
ABSTRACT:
SUBMITTER: Stiegler AL
PROVIDER: S-EPMC6501215 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Stiegler Amy L AL Boggon Titus J TJ
Biochemical Society transactions 20181204 6
Pseudoenzymes generally lack detectable catalytic activity despite adopting the overall protein fold of their catalytically competent counterparts, indeed 'pseudo' family members seem to be incorporated in all enzyme classes. The small GTPase enzymes are important signaling proteins, and recent studies have identified many new family members with noncanonical residues within the catalytic cleft, termed pseudoGTPases. To illustrate recent discoveries in the field, we use the p190RhoGAP proteins a ...[more]