Ontology highlight
ABSTRACT:
SUBMITTER: Evripioti AA
PROVIDER: S-EPMC6501904 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Evripioti Antonia Alexandra AA Ortega-Prieto Ana Maria AM Skelton Jessica Katy JK Bazot Quentin Q Dorner Marcus M
Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20190501 1773
Hepatitis B virus (HBV) entry into hepatocytes is mediated via a high-affinity interaction between the preS1 glycoprotein and sodium/bile acid cotransporting polypeptide (NTCP). To date, in vitro model systems rely on high multiplicities of infection to achieve infection of cell lines overexpressing human NTCP. This study investigates a novel regulatory pathway for NTCP trafficking to the cell surface, induced by DMSO-mediated cellular differentiation. DMSO rapidly induces high cell surface expr ...[more]