Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC6173519 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Liu Yuan Y Gordesky-Gold Beth B Leney-Greene Michael M Weinbren Nathan L NL Tudor Matthew M Cherry Sara S
Cell host & microbe 20180619 1
The emerging arthropod-borne flavivirus Zika virus (ZIKV) is associated with neurological complications. Innate immunity is essential for the control of virus infection, but the innate immune mechanisms that impact viral infection of neurons remain poorly defined. Using the genetically tractable Drosophila system, we show that ZIKV infection of the adult fly brain leads to NF-kB-dependent inflammatory signaling, which serves to limit infection. ZIKV-dependent NF-kB activation induces the express ...[more]