Dataset Information

Potential protein markers for breast cancer recurrence: a retrospective cohort study.

ABSTRACT:

Background

We evaluated five key proteins involved in various cancer-related pathways and assessed their relation to breast cancer recurrence.

Methods

We used the Kentucky Cancer Registry to retrospectively identify primary invasive breast cancer cases (n = 475) that were diagnosed and treated at University of Kentucky Medical Center between 2000 and 2007. Breast cancer recurrence was observed in 62 cases during the 5-year follow-up after diagnosis. Protein expression or activity level was analyzed from surgery tissue using immuno-histochemical assays.

Results

Compared to ER+/PR+/HER2- patients without recurrence, those with recurrence had higher TWIST expression (p = 0.049) but lower ABL1/ABL2 activity (p = 0.003) in primary tumors. We also found that triple-negative breast cancer patients with recurrence had higher SNAI1 expression compared to those without recurrence (p = 0.03). After adjusting for potential confounders, the higher ABL1/ABL2 activity in primary tumors was associated with a decreased risk of recurrence (OR 0.72, 95% CI 0.85-0.90) among ER+/PR+/HER2- patients. In addition, among patients with recurrence we observed that the activity level of ABL1/ABL2 was significantly increased in recurrent tumors compared to the matched primary tumors regardless of the subtype (p = 0.013).

Conclusions

These findings provide evidence that the expression/activity level of various proteins may be differentially associated with risk of recurrence of breast tumor subtypes.

SUBMITTER: He C

PROVIDER: S-EPMC6502759 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature

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Publications

Potential protein markers for breast cancer recurrence: a retrospective cohort study.

He Chunyan C Plattner Rina R Rangnekar Vivek V Zhou Binhua B Liu Chunming C Stewart Rachel L RL Huang Bin B Wang Chi C Tucker Thomas C TC

Cancer causes & control : CCC 20181128 1

<h4>Background</h4>We evaluated five key proteins involved in various cancer-related pathways and assessed their relation to breast cancer recurrence.<h4>Methods</h4>We used the Kentucky Cancer Registry to retrospectively identify primary invasive breast cancer cases (n = 475) that were diagnosed and treated at University of Kentucky Medical Center between 2000 and 2007. Breast cancer recurrence was observed in 62 cases during the 5-year follow-up after diagnosis. Protein expression or activity ...[more]

PMID: 30488343

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Dataset Information

Potential protein markers for breast cancer recurrence: a retrospective cohort study.

Background

Methods

Results

Conclusions

Publications

Potential protein markers for breast cancer recurrence: a retrospective cohort study.

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