Ontology highlight
ABSTRACT:
SUBMITTER: Vinik Y
PROVIDER: S-EPMC7852393 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Vinik Yaron Y Ortega Francisco Gabriel FG Mills Gordon B GB Lu Yilling Y Jurkowicz Menucha M Halperin Sharon S Aharoni Mor M Gutman Mordechai M Lev Sima S
Science advances 20201002 40
Proteomic profiling of circulating small extracellular vesicles (sEVs) represents a promising, noninvasive approach for early detection and therapeutic monitoring of breast cancer (BC). We describe a relatively low-cost, fast, and reliable method to isolate sEVs from plasma of BC patients and analyze their protein content by semiquantitative proteomics. sEV-enriched fractions were isolated from plasma of healthy controls and BC patients at different disease stages before and after surgery. Prote ...[more]